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Traditional Treatments for Peyronies Disease

Weighing the Evidence

Traditional treatments are defined as treatments that have been widely prescribed, recommended, or practiced by doctors having an interest in, and experience with Peyronie's Disease. As with all treatments, individual physicians have their preferred treatments and many of these treatments may not be available from a given physician.  Also keep in mind that this is not an all inclusive list but cover the most currently most common traditional treatments.


Non-invasive treatments include oral and topical treatments that have been widely recommended or prescribed by doctors over the years, and that continue to be prescribed.  As with most treatments, different doctors prefer and recommend different traditional treatments.

Vitamin E - Varying types of this over the counter vitamin is often recommended in varying doses.  We know of no clinical studies that have ever established the effectiveness of vitamin E for Peyronie's Disease.  The risks and cost of this vitamin is low so many incorporate this into their treatment plan with a "what can it hurt attitude"

Cholchicine - This is a prescription medication long used for gout.  It is thought to reduce inflammation during acute phases of Peyronies Disease.  It also is known to interfere with the formation of scar tissue.  We know of no objective clinical studies that have been made on Cholchicine and its effectiveness with any phase of Peyronies Disease.  Cholchicine often has the side effect of stomach upset and diarhea (which often resolves in the initial weeks).  It also can have less common but more serious side effects such as suppression of white blood cell production.

Potaba  - (Aminobenzoate Potassium) Potaba is used to treat fibrosis, a condition in which the skin and underlying tissues tighten and become less flexible. This condition occurs in such diseases as dermatomyositis, morphea, scleroderma, and Peyronie's disease. The dosage on this medication is often 24 pills a day and it is very common for it to cause significant upset of the digestive system and nausea.  While some limited studies have show it to stop the progression of acute Peyronies Disease, these studies are limited.  We know of no studies that indicate any reversal.


Verapamil intraleasional Injections (VI) or (ILV) - Trained Urologists can inject Verapamil, a calcium channel blocker, directly into the plaque. This is referred to as Verapamil Injections (VI) or Intralesional Verapamil (ILV).  The verapamil is intended to break down scar tissue deposits and result in replacement with healthy tissue.  The process requires several injections over a period of months.

Reports of success from VI vary greatly.  Many men on our forum have, or are currently receiving VI treatment.  There is mixed opinion, but the prevailing opinion currently seems to be unfavorable.  (To see the our survey results click HERE )

Surgery - Is almost always reserved for those at least 18 months from the onset of Peyronies Disease that are unable to have intercourse.  This is considered a last line option after all else has failed.  There are different types of corrective surgery depending on the symptoms and the surgeon's specialty.  Expert penile surgeons are uncommon.  The importance of seeking out a very skilled surgeon cannot be over emphasized.

Nesbit tuck - Tissue on the opposite side of the penis is removed or pinched, canceling the
bending effect. This surgery shortens the long side of the penis to match the constricted
side in order to cancel the bend. (see illustration)


This  procedure is ineffective for narrowing or hourglass deformity




Plaque excision. - The plaque is removed and replaced with a patch of skin.

Plaque incision with graft. Several cuts are made in the plaque, this allows straightening. The cut plaque is then covered with a grafted which can include one of several materials.

Prosthesis Implant - All natural erectile tissue is removed from the penis and one of several types of prosthesis is implanted.  The most advanced of these are hydraulic manual pump with the fluid reservoir implanted in the lower abdomen and the miniature pumps in the scrotum.  With a hydraulic implant the penis increases in girth when pumped to an erect state but not in length.

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